Spidey's Steve Ditko designed rouges gallery is one of the sweetest and most visually awesome bunch of crooks in the whole Marvel U, and while some have recently been updated, made more sinister or replaced, their classic look and motivations still have plenty of possibilities to explore.
Sure Venom would just scratch inside the adventures of '80's Forever Spidey' but even then it wouldn't be the end of the world if he didn't. I mean just look at this variant cover to Amazing Spider-Man #645 by Bryan Hitch! Vulture... Sandman... Mysterio... just damn. If this was the cover to 80's Spidey #1 I would be one happy little dude.